Michael N Diringer Selected Research

Nimodipine (Modus)

12/2020	NEWTON-2 Cisternal (Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage): A Phase 2, Multicenter, Randomized, Open-Label Safety Study of Intracisternal EG-1962 in Aneurysmal Subarachnoid Hemorrhage.
1/2020	Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid Hemorrhage.
12/2019	Nimodipine pharmacokinetics after intraventricular injection of sustained-release nimodipine for subarachnoid hemorrhage.
1/2019	Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)].
1/2017	Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]).
10/2015	NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage.
10/2014	Treatment of subarachnoid hemorrhage.

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Michael N Diringer Research Topics

Disease

22	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 12/2020 - 07/2005
15	Cerebral Hemorrhage 01/2021 - 01/2005
12	Brain Ischemia (Cerebral Ischemia) 12/2020 - 09/2009
7	Brain Injuries (Brain Injury) 01/2021 - 01/2002
7	Cerebral Infarction 12/2020 - 02/2005
6	Ischemia 04/2017 - 07/2005
6	Hypertension (High Blood Pressure) 01/2016 - 09/2005
6	Craniocerebral Trauma (Head Injury) 01/2016 - 03/2006
6	Ischemic Stroke 04/2015 - 10/2004
6	Hemorrhage 01/2010 - 06/2005
6	Hematoma 05/2008 - 01/2005
5	Brain Edema (Cerebral Edema) 01/2016 - 05/2002
5	Intracranial Aneurysm (Cerebral Aneurysm) 08/2012 - 05/2002
4	Infarction (Infarctions) 12/2020 - 02/2011
4	Coma (Comas) 01/2020 - 10/2006
4	Fever (Fevers) 12/2011 - 02/2004
3	Consciousness Disorders 01/2021 - 01/2020
3	Hypotension (Low Blood Pressure) 01/2020 - 01/2017
3	Anemia 04/2017 - 09/2009
3	Heart Arrest (Cardiac Arrest) 10/2016 - 01/2011
3	Intracranial Hypertension 11/2015 - 04/2007
3	Aneurysm (Aneurysms) 05/2013 - 04/2005
3	Stroke (Strokes) 12/2012 - 01/2003
3	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2012 - 04/2007
3	Infections 12/2012 - 02/2004
2	Delirium 12/2012 - 01/2011
2	Critical Illness (Critically Ill) 12/2011 - 02/2004
2	Edema (Dropsy) 02/2011 - 01/2005
2	Seizures (Absence Seizure) 02/2011 - 01/2008
2	Sepsis (Septicemia) 01/2011 - 01/2008
2	Hemorrhagic Stroke 01/2010 - 03/2009
2	Atherosclerosis 01/2010 - 03/2008
2	Body Weight (Weight, Body) 05/2008 - 02/2005
2	Hyperoxia 04/2008 - 04/2007
2	Mitochondrial Diseases (Mitochondrial Disease) 04/2008 - 10/2006
2	Hypothermia 01/2008 - 05/2002
1	Sickle Cell Anemia (Hemoglobin S Disease) 12/2017
1	Hydrocephalus (Hydrocephaly) 10/2014
1	Wounds and Injuries (Trauma) 02/2014
1	Inflammation (Inflammations) 01/2011
1	Central Nervous System Diseases (CNS Diseases) 10/2010
1	Bacteremia 04/2010
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2010
1	Neurologic Manifestations (Neurological Manifestations) 10/2009
1	Myocardial Ischemia (Ischemic Heart Diseases) 03/2008
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2008

Drug/Important Bio-Agent (IBA)

14	Oxygen (Dioxygen)IBA 12/2017 - 01/2002
11	recombinant FVIIa (rFVIIa)FDA Link 01/2010 - 01/2005
11	Factor VIIa (Activated Factor VII)IBA 01/2010 - 02/2005
7	Nimodipine (Modus)FDA LinkGeneric 12/2020 - 10/2014
7	Mannitol (Osmitrol)FDA LinkGeneric 01/2016 - 09/2005
5	Hemostatics (Antihemorrhagics)IBA 09/2012 - 01/2006
4	EG-1962IBA 12/2020 - 01/2017
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2011
4	Factor VII (Proconvertin)IBA 01/2010 - 01/2005
3	Pharmaceutical PreparationsIBA 01/2019 - 03/2008
3	Hemoglobins (Hemoglobin)IBA 12/2017 - 09/2009
3	SodiumIBA 10/2010 - 05/2006
2	Delayed-Action PreparationsIBA 01/2020 - 12/2019
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2016 - 12/2012
2	Acetaminophen (Paracetamol)FDA LinkGeneric 12/2011 - 02/2004
2	Anti-Bacterial Agents (Antibiotics)IBA 04/2010 - 02/2004
2	TESIBA 01/2010 - 03/2008
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2010 - 03/2007
2	Troponin IIBA 05/2006 - 01/2005
1	PF-05230907IBA 01/2021
1	PEGylated carboxyhemoglobin bovineIBA 12/2017
1	Carbon MonoxideIBA 12/2017
1	Simvastatin (Zocor)FDA LinkGeneric 01/2016
1	1,1'- (4,4,7,7- tetramethyl- 4,7- diazaundecamethylene)bis- 4- (3- methyl- 2,3- dihydro(benzo- 1,3- thiazole)- 2- methylidene)quinolinium (TOTO)IBA 11/2015
1	Ringer's LactateIBA 04/2013
1	Erythropoietin FDA Link 12/2012
1	Ibuprofen (Motrin)FDA LinkGeneric 12/2011
1	CalciumIBA 12/2011
1	AntipyreticsIBA 12/2011
1	Levetiracetam (Keppra)FDA LinkGeneric 02/2011
1	Phenytoin (Dilantin)FDA LinkGeneric 02/2011
1	PlatinumIBA 04/2010
1	HematinicsIBA 02/2010
1	CytokinesIBA 02/2010
1	Verapamil (Calan)FDA LinkGeneric 10/2009
1	Vasodilator Agents (Vasodilators)IBA 02/2009
1	BenzodiazepinesIBA 01/2008
1	BarbituratesIBA 01/2008
1	barbituric acid (barbiturate)IBA 01/2008
1	Midazolam (Versed)FDA LinkGeneric 01/2008
1	Pentobarbital (Nembutal)FDA Link 01/2008
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2008

Therapy/Procedure

23	Therapeutics 01/2021 - 05/2002
8	Critical Care (Surgical Intensive Care) 10/2016 - 06/2006
4	Induced Hypothermia 06/2015 - 10/2006
4	Catheters 05/2013 - 02/2004
2	Artificial Respiration (Mechanical Ventilation) 02/2014 - 06/2006
2	Erythrocyte Transfusion 01/2011 - 09/2009
1	Precision Medicine 01/2021
1	Intraventricular Injections 12/2019
1	Intravenous Administration 12/2017
1	Airway Management 10/2014
1	Surgical Decompression 12/2012
1	Blood Transfusion (Blood Transfusions) 03/2012